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1431468-36-8Cabozantinib Impurity 3

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Catalogue No.:	VE0028099
CAS No.:	1431468-36-8
Mol. Formula:	C17H14F2N2O2
Mol. Weight:	316.30 g/mol

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Additional information on CAS 1431468-36-8

Parent drug

Cabozantinib

IUPAC Name

N,N’-Bis(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

Pharmacopeial Synonyms

N/A

Synonyms

N/A

Smiles

O=C(NC1=CC=C(C=C1)F)C2(C(NC3=CC=C(C=C3)F)=O)CC2

InChI

InChI=1S/C17H14F2N2O2/c18-11-1-5-13(6-2-11)20-15(22)17(9-10-17)16(23)21-14-7-3-12(19)4-8-14/h1-8H,9-10H2,(H,20,22)(H,21,23)

Description

Cabozantinib Impurity 3 (CAS 1431468-36-8) is a characterized synthetic and degradation-related byproduct observed during active pharmaceutical ingredient manufacture and stability studies. Analytical characterization typically includes HPLC/UPLC retention behavior, LC-MS and HRMS exact mass confirmation, and 1H and 13C NMR structural assignment to support impurity identification. Quantitative profiling and forced degradation studies inform specification limits and control strategies to mitigate formation during synthesis and storage. Isolation protocols and validated stability-indicating methods enable accurate quantitation and batch release testing. Data support regulatory impurity qualification, root cause analysis, and process optimization to ensure consistent impurity control.