Canagliflozin Ring opening impurity
Canagliflozin Ring opening impurity Or (2S,3R,4R,5R)-1-(3-((5-(4-fluorophenyl)thiophene-2-yl)methyl)-4-methylphenyl)hexane-1,2,3,4,5,6-hexanol, ring-opening product isomer degraded produces under high temperature, Canagliflozin inhibiting the transporter protein SGLT2 in the kidneys, which reduces renal glucose reabsorption.
(2S, 3R, 4R, 5R)-1-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)hexane-1, 2, 3, 4, 5, 6-hexaol
Sci-Hub, Carbohydrate malabsorption mechanism for tumor formation in rats treated with the SGLT2 inhibitor canagliflozin, 10.1016/j.cbi.2014.08.001. (2014). Retrieved December 31, 2021, from Sci-hub.ee website: https://sci-hub.ee/10.1016/j.cbi.2014.08.001