Canagliflozin Ring Opening Impurity
Ring-opening product isomer degraded produces under high temperature, Canagliflozin inhibiting the transporter protein SGLT2 in the kidneys, which reduces renal glucose reabsorption.
Additional information on Canagliflozin Ring Opening Impurity
(2S, 3R, 4R, 5R)-1-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)hexane-1, 2, 3, 4, 5, 6-hexaol
Sci-Hub, Carbohydrate malabsorption mechanism for tumor formation in rats treated with the SGLT2 inhibitor canagliflozin, 10.1016/j.cbi.2014.08.001. (2014). Retrieved December 31, 2021, from Sci-hub.ee website: https://sci-hub.ee/10.1016/j.cbi.2014.08.001
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