Celecoxib Carboxylic Acid Acyl-β-D-Glucuronide Benzyl Ester
It is one of impurity present in celecoxib. Celecoxib is a selective cyclooxygenase-2 inhibitor, By inhibiting prostaglandin synthesis non-steroidal anti-inflammatory drugs cause mucosal damage and ulceration. Celecoxib poses less of an ulceration risk than other NSAIDS, owing to its decreased effect on gastric mucosal prostaglandin synthesis when compared to placebo, also they exert anticancer effects by binding to the cadherin-11 protein, which is involved in the progression of tumors and inhibiting the 3 phosphoinositide-dependent kinase-1 signaling mechanism, which is used to treat osteoarthritis, rheumatoid arthritis, and to reduce polyps in familial adenomatous polyposis.
Additional information on Celecoxib Carboxylic Acid Acyl-β-D-Glucuronide Benzyl Ester
VE007715
N/A
C30H26F3N3O10S
677.6 g/mol
Celecoxib
(2S, 3S, 5R, 6S)-benzyl 3, 4, 5-trihydroxy-6-((4-(1-(4-sulfamoylphenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)benzoyl)oxy)tetrahydro-2H-pyran-2-carboxylate
N/A
Xu, C., Gu, K., Yasen, Y., & Hou, Y. (2016). Efficacy and Safety of Celecoxib Therapy in Osteoarthritis. Medicine, 95(20), e3585. https://doi.org/10.1097/md.0000000000003585
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Name of Impurity | Catalogue No. | |
---|---|---|
Celecoxib 2 methyl analog | VL30010 | View CAS 170569-99-0 |
Celecoxib 2, 5-Dimethyl | VE007712 | View CAS 457639-26-8 |
Celecoxib Bromo Impurity | VE007713 | View CAS 170570-75-9 |
Celecoxib Carboxylic Acid Acyl-β-D-Glucuronide | VE007714 | View CAS 264236-79-5 |
Celecoxib Carboxylic Acid Methyl Ester | VE007716 | View CAS 1189893-75-1 |
Celecoxib EP Impurity A | VL30003 | View CAS 170570-01-1 |
Celecoxib EP Impurity B | VL30001 | View CAS 331943-04-5 |
Celecoxib Hydrazine Impurity | VL30015 | View CAS 17852-52-7 |
Celecoxib Impurity 10 | VE008690 | View CAS 219986-64-8 |
Celecoxib Impurity 11 | VE007646 | View |
Celecoxib Impurity 2 | VL30002 | View |
Celecoxib Impurity 5 | VE006161 | View CAS 1061214-09-2 |
Celecoxib Impurity III | VL30012 | View CAS 170569-87-6 |
Celecoxib Impurity IV | VL30011 | View CAS 1803258-57-2 |
Celecoxib Inhouse Impurity | VE006154 | View CAS 53764-99-1 |
Celecoxib N-Oxide | VE008322 | View |
Celecoxib Peroxide | VE009608 | View CAS 2247197-65-3 |
Celecoxib Related Compound 4 | VL30014 | View CAS 720-94-5 |
Celecoxib Related Compound C | VL30004 | View CAS 170570-09-9 |
Celecoxib Related Compound D | VL30009 | View CAS 1061214-06-9 |
Celecoxib Schiff's Base Analog | VE008689 | View |
Celecoxib carboxylic acid impurity | VL30008 | View CAS 170571-01-4 |
Celiprolol EP Impurity C | VE008691 | View CAS 57471-01-9 |