Celecoxib Carboxylic Acid Acyl-β-D-Glucuronide Benzyl Ester

It is one of impurity present in celecoxib. Celecoxib is a selective cyclooxygenase-2 inhibitor, By inhibiting prostaglandin synthesis non-steroidal anti-inflammatory drugs cause mucosal damage and ulceration. Celecoxib poses less of an ulceration risk than other NSAIDS, owing to its decreased effect on gastric mucosal prostaglandin synthesis when compared to placebo, also they exert anticancer effects by binding to the cadherin-11 protein, which is involved in the progression of tumors and inhibiting the 3 phosphoinositide-dependent kinase-1 signaling mechanism, which is used to treat osteoarthritis, rheumatoid arthritis, and to reduce polyps in familial adenomatous polyposis.

Additional information on Celecoxib Carboxylic Acid Acyl-β-D-Glucuronide Benzyl Ester

Catalogue No.

VE007715

CAS No.

N/A

Molecular Formula

C30H26F3N3O10S

Molecular Weight

677.6 g/mol

Parent drug

Celecoxib

IUPAC Name

(2S, 3S, 5R, 6S)-benzyl 3, 4, 5-trihydroxy-6-((4-(1-(4-sulfamoylphenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)benzoyl)oxy)tetrahydro-2H-pyran-2-carboxylate

Synonyms

N/A

References

Xu, C., Gu, K., Yasen, Y., & Hou, Y. (2016). Efficacy and Safety of Celecoxib Therapy in Osteoarthritis. Medicine, 95(20), e3585. https://doi.org/10.1097/md.0000000000003585

Status

In-stock

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Celecoxib Carboxylic Acid Acyl-β-D-Glucuronide Benzyl Ester

Celecoxib Carboxylic Acid Acyl-β-D-Glucuronide Benzyl Ester
Catalogue No.

VE007715

CAS No.

N/A

Molecular Formula

C30H26F3N3O10S

Molecular Weight

677.6 g/mol

Parent drug

Celecoxib

IUPAC Name

(2S, 3S, 5R, 6S)-benzyl 3, 4, 5-trihydroxy-6-((4-(1-(4-sulfamoylphenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)benzoyl)oxy)tetrahydro-2H-pyran-2-carboxylate

Synonyms

N/A

References

Xu, C., Gu, K., Yasen, Y., & Hou, Y. (2016). Efficacy and Safety of Celecoxib Therapy in Osteoarthritis. Medicine, 95(20), e3585. https://doi.org/10.1097/md.0000000000003585

Status

In-stock

ListName

Celecoxib Carboxylic Acid Acyl-β-D-Glucuronide Benzyl Ester

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