Celecoxib Carboxylic Acid Acyl-β-D-Glucuronide Benzyl Ester

Status: In-stock

It is one of impurity present in celecoxib. Celecoxib is a selective cyclooxygenase-2 inhibitor, By inhibiting prostaglandin synthesis non-steroidal anti-inflammatory drugs cause mucosal damage and ulceration. Celecoxib poses less of an ulceration risk than other NSAIDS, owing to its decreased effect on gastric mucosal prostaglandin synthesis when compared to placebo, also they exert anticancer effects by binding to the cadherin-11 protein, which is involved in the progression of tumors and inhibiting the 3 phosphoinositide-dependent kinase-1 signaling mechanism, which is used to treat osteoarthritis, rheumatoid arthritis, and to reduce polyps in familial adenomatous polyposis.

Additional information on Celecoxib Carboxylic Acid Acyl-β-D-Glucuronide Benzyl Ester

Catalogue No. VE007715
CAS No. N/A
Molecular Formula C30H26F3N3O10S
Molecular Weight 677.6 g/mol
Parent drug Celecoxib
IUPAC Name (2S, 3S, 5R, 6S)-benzyl 3, 4, 5-trihydroxy-6-((4-(1-(4-sulfamoylphenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)benzoyl)oxy)tetrahydro-2H-pyran-2-carboxylate
Synonyms N/A
References Xu, C., Gu, K., Yasen, Y., & Hou, Y. (2016). Efficacy and Safety of Celecoxib Therapy in Osteoarthritis. Medicine, 95(20), e3585. https://doi.org/10.1097/md.0000000000003585
Status In-stock

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Celecoxib Carboxylic Acid Acyl-β-D-Glucuronide Benzyl Ester

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