264236-79-5: Celecoxib Carboxylic Acid Acyl-β-D-Glucuronide

Status: In-stock

It is one of impurity present in Celecoxib. Celecoxib is a selective cyclooxygenase-2 (COX-2) inhibitor, which is a nonsteroidal anti-inflammatory drug, COX-2 is inflamed tissues, and it is induced by inflammatory mediators. inhibition of this enzyme reduces the synthesis of metabolites that include prostaglandin E2, prostacyclin, thromboxane, prostaglandin D2 and prostaglandin F2 inhibition of these mediators leads to the alleviation of pain and inflammation. Celecoxib poses less of an ulceration risk than other NSAIDS, owing to its decreased effect on gastric mucosal prostaglandin synthesis, which is used to treat osteoarthritis, rheumatoid arthritis, acute pain, and menstrual symptoms.

Additional information on CAS 264236-79-5

Catalogue No. VE007714
CAS No. 264236-79-5
Molecular Formula C23H20F3N3O10S
Molecular Weight 587.48 g/mol
Parent drug Celecoxib
IUPAC Name 1-[4-[1-[4-(Aminosulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazol-5-yl]benzoate] β-D-glucopyranuronic acid
Synonyms N/A
References Gong, L., Thorn, C. F., Bertagnolli, M. M., Grosser, T., Altman, R. B., & Klein, T. E. (2012). Celecoxib pathways. Pharmacogenetics and Genomics, 22(4), 310–318. https://doi.org/10.1097/fpc.0b013e32834f94cb
Status In-stock

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264236-79-5: Celecoxib Carboxylic Acid Acyl-β-D-Glucuronide

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