1189893-75-1: Celecoxib Carboxylic Acid Methyl Ester
It is one of impurity present in Celecoxib. Celecoxib is a selective cyclooxygenase-2 (COX-2) inhibitor, which is a nonsteroidal anti-inflammatory drug, COX-2 is inflamed tissues, and it is induced by inflammatory mediators. inhibition of this enzyme reduces the synthesis of metabolites that include prostaglandin E2, prostacyclin, thromboxane, prostaglandin D2 and prostaglandin F2 inhibition of these mediators leads to the alleviation of pain and inflammation. Celecoxib poses less of an ulceration risk than other NSAIDS, owing to its decreased effect on gastric mucosal prostaglandin synthesis, which is used to treat osteoarthritis, rheumatoid arthritis, acute pain, and menstrual symptoms.
Additional information on CAS 1189893-75-1
VE007716
1189893-75-1
C18H14F3N3O4S
425.38 g/mol
Celecoxib
4-[1-[4-(Aminosulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazol-5-yl]benzoic acid methyl ester
N/A
Gong, L., Thorn, C. F., Bertagnolli, M. M., Grosser, T., Altman, R. B., & Klein, T. E. (2012). Celecoxib pathways. Pharmacogenetics and Genomics, 22(4), 310–318. https://doi.org/10.1097/fpc.0b013e32834f94cb
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Celecoxib 2, 5-Dimethyl | VE007712 | View CAS 457639-26-8 |
Celecoxib Bromo Impurity | VE007713 | View CAS 170570-75-9 |
Celecoxib Carboxylic Acid Acyl-β-D-Glucuronide | VE007714 | View CAS 264236-79-5 |
Celecoxib Carboxylic Acid Acyl-β-D-Glucuronide Benzyl Ester | VE007715 | View |
Celecoxib EP Impurity A | VL30003 | View CAS 170570-01-1 |
Celecoxib EP Impurity B | VL30001 | View CAS 331943-04-5 |
Celecoxib Hydrazine Impurity | VL30015 | View CAS 17852-52-7 |
Celecoxib Impurity 10 | VE008690 | View CAS 219986-64-8 |
Celecoxib Impurity 11 | VE007646 | View |
Celecoxib Impurity 2 | VL30002 | View |
Celecoxib Impurity 5 | VE006161 | View CAS 1061214-09-2 |
Celecoxib Impurity III | VL30012 | View CAS 170569-87-6 |
Celecoxib Impurity IV | VL30011 | View CAS 1803258-57-2 |
Celecoxib Inhouse Impurity | VE006154 | View CAS 53764-99-1 |
Celecoxib N-Oxide | VE008322 | View |
Celecoxib Peroxide | VE009608 | View CAS 2247197-65-3 |
Celecoxib Related Compound 4 | VL30014 | View CAS 720-94-5 |
Celecoxib Related Compound C | VL30004 | View CAS 170570-09-9 |
Celecoxib Related Compound D | VL30009 | View CAS 1061214-06-9 |
Celecoxib Schiff's Base Analog | VE008689 | View |
Celecoxib carboxylic acid impurity | VL30008 | View CAS 170571-01-4 |
Celiprolol EP Impurity C | VE008691 | View CAS 57471-01-9 |