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54707-71-0Clonidine EP Impurity B
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| Catalogue No.: | VL281008 |
|---|---|
| CAS No.: | 54707-71-0 |
| Mol. Formula: | C11H11Cl2N3O |
| Mol. Weight: | 272.13 g/mol |
Additional information on CAS 54707-71-0
Parent drug
ClonidineIUPAC Name
1-Acetyl-2-[(2,6-dichlorophenyl)amino]-4,5-dihydro-1H-imidazolePharmacopoeial Synonyms
Clonidine Related Compound AOther Synonyms
1-Acetyl-2-(2,6-dichlorophenylimino)-imidazolidinAcetylclonidine; N-(2,6-Dichlorophenyl)-4,5-dihydro-1H-imidazol-2-amine; 2-((2,6-Dichlorophenyl)imino)imidazolidineSmiles
ClC1=CC=CC(Cl)=C1NC2=NCCN2C(C)=OInChI
InChI=1S/C11H11Cl2N3O/c1-7(17)16-6-5-14-11(16)15-10-8(12)3-2-4-9(10)13/h2-4H,5-6H2,1H3,(H,14,15)Description
Clonidine EP Impurity B, also designated Clonidine Related Compound A or acetylclonidine, is a structurally defined process impurity of clonidine with the molecular formula C11H11Cl2N3O and molecular weight 272.13 g/mol; CAS 54707-71-0. It is an acylated clonidine analogue bearing a methyl ketone function, consistent with formation during synthetic intermediates handling or acylation-related side reactions rather than simple oxidative degradation. Owing to its close chromatographic and mass spectral proximity to the parent drug, characterization commonly relies on RP-LC coupled with UV, LC-MS/MS, and, when needed, HRMS or NMR confirmation. Its presence is relevant to impurity profiling under pharmacopeial specifications and ICH Q3A/Q3B assessment.References
Aronstam, Robert S., et al. “Clonidine Protection from Soman and Echothiophate Toxicity in Mice.†Life Sciences, vol. 39, no. 22, Dec. 1986, pp. 2097–102, https://doi.org/10.1016/0024-3205(86)90361-9. ?Gold, Mark S. “Opiate Withdrawal Using Clonidine.†JAMA, vol. 243, no. 4, Jan. 1980, p. 343, https://doi.org/10.1001/jama.1980.03300300021018.Request a Quote
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