1009107-27-0: Daclatasvir RSSR Isomer

Daclatasvir RSSR Isomer (CAS No.: 1009107-27-0) or N,N’-[[1,1′-Biphenyl]-4,4′-diylbis[1H-imidazole-5,2-diyl-(2S)-2,1-pyrrolidinediyl[(1R)-1-(1-methylethyl)-2-oxo-2,1-ethanediyl]]]biscarbamic Acid C,C’-Dimethyl Ester is an isomer of Daclatasvir. Daclatasvir is a highly selective, hepatitis C virus and non-structural protein 5a polymerase replication complex blocker with picomolar potency and has broad genotypic coverage in vitro.

Additional information

Catalogue No.

VE006848

CAS No.

1009107-27-0

Molecular Formula

C40H50N8O6

Molecular Weight

738.88

IUPAC Name

N, N'-[[1, 1'-Biphenyl]-4, 4'-diylbis[1H-imidazole-5, 2-diyl-(2S)-2, 1-pyrrolidinediyl[(1R)-1-(1-methylethyl)-2-oxo-2, 1-ethanediyl]]]biscarbamic Acid C, C'-Dimethyl Ester

References

Srinivasu, G., et al. “Development and Validation of the Chiral HPLC Method for Daclatasvir in Gradient Elution Mode on Amylose-Based Immobilized Chiral Stationary Phase.” Chromatographia, vol. 79, no. 21-22, Sept. 2016, pp. 1457–67, https://doi.org/10.1007/s10337-016-3157-2.?Gandhi, Yash, et al. “Daclatasvir: A Review of Preclinical and Clinical Pharmacokinetics.” Clinical Pharmacokinetics, vol. 57, no. 8, Jan. 2018, pp. 911–28, https://doi.org/10.1007/s40262-017-0624-3.?

Status

In-stock