Dapagliflozin Impurity 15, also designated Dapagliflozin Despyranose Bromo Impurity, CAS 461432-23-5, is a halogenated process-related impurity associated with structural modification of the dapagliflozin scaffold through loss of the pyranose moiety and introduction of bromine. The compound has molecular formula C15H14BrClO and molecular weight 325.63 g/mol, indicating a lipophilic aromatic ether halide. Its occurrence is typically linked to synthetic intermediate carryover or halogenation side reactions during manufacture. Because such impurities can influence specification setting, profiling by LC-MS/MS, LC-HRMS, and orthogonal HPLC with UV or CAD detection is commonly required for definitive identification and quantification.
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