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Includes: HPLC, MASS/LC-MS, 1H NMR, FT-IR, Potency, Structure Elucidation Report (SER), and additional analytical data depending on the product.

6762-51-2Dexamethasone-Δ 17,20 21-Aldehyde

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Catalogue No.:	VL273003
CAS No.:	6762-51-2
Mol. Formula:	C22H27FO4
Mol. Weight:	374.45 g/mol

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Additional information on CAS 6762-51-2

Parent drug

Dexamethasone

IUPAC Name

9-Fluoro-11β, 20-dihydroxy-16α-methyl-3-oxopregna-1, 4, 17(20)-trien-21-al

Pharmacopoeial Synonyms

N/A

Other Synonyms

(Z)-9-Fluoro-11ß,20-dihydroxy-16a-methylpregna-1,4,17(20)-triene-3,21-dione; (11β, 16α)-9-Fluoro-11, 20-dihydroxy-16-methyl-3-oxopregna-1, 4, 17(20)-trien-21-al

Smile

C[C@@H]\1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2(/C1=C(/C=O)\O)C)O)F)C

InChI

InChI=1S/C22H27FO4/c1-12-8-16-15-5-4-13-9-14(25)6-7-21(13,3)22(15,23)18(27)10-20(16,2)19(12)17(26)11-24/h6-7,9,11-12,15-16,18,26-27H,4-5,8,10H2,1-3H3/b19-17-/t12-,15+,16+,18+,20+,21+,22+/m1/s1

Characterization Data (Included)

HPLC, MASS/LC-MS, 1H NMR, FT-IR, Potency, and Structure Elucidation Report (SER).

Additional Characterization Data

QNMR, D2O Exchange, 13C NMR, 13C APT, COSY NMR, NOESY NMR, 15N NMR, HSQC NMR, HMQC NMR, and HMBC NMR. These are available upon request and may be free or subject to additional charges.

Description

Dexamethasone-Δ 17,20 21-Aldehyde is a meticulously characterized reference material that complies with rigorous regulatory requirements, including those defined by USP, EMA, JP, and BP. This product plays a crucial role in Abbreviated New Drug Applications (ANDA), New Drug Applications (NDA), and the commercial manufacturing of Dexamethasone. It is further supported by a detailed Structure Elucidation Report (SER), ensuring high accuracy and reliability across a broad range of analytical applications. Dexamethasone-Δ 17,20 21-Aldehyde is an impurity of Dexamethasone. is an impurity of Dexamethasone which is the first compound to extensively better the survival in an RCT in COVID-19 patients. It is also an extensively used drug that is widely evaluated and cost-effective.

References

“ISOLATION, IDENTIFICATION, and CHARACTERIZATION of 17-OXO DEXAMETHASONE, an OXIDATIVE DEGRADATION IMPURITY of DEXAMETHASONE USING FLASH CHROMATOGRAPHY and NMR/HRMS/IR.” Journal of Liquid Chromatography & Related Technologies, 2014, www.tandfonline.com/doi/abs/10.1080/10826076.2013.836712.? Lammers, Twan, et al. “Dexamethasone Nanomedicines for COVID-19.” Nature Nanotechnology, vol. 15, no. 8, Aug. 2020, pp. 622–24, https://doi.org/10.1038/s41565-020-0752-z.?