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Includes: HPLC, MASS/LC-MS, 1H NMR, FT-IR, Potency, Structure Elucidation Report (SER), and additional analytical data depending on the product.

Disodium, (2R,4S)-5-([1,1'- biphenyl]-4-yl)-4-(3- carboxypropanamido)-2-methylvalerate

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Catalogue No.:	VE0026765
CAS No.:	N/A
Mol. Formula:	C22H23NNa2O5
Mol. Weight:	427.40 g/mol

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Additional information on

Parent drug

Sacubitril

IUPAC Name

Disodium, (2R,4S)-5-([1,1′- biphenyl]-4-yl)-4-(3- carboxypropanamido)-2-methylvalerate

Pharmacopeial Synonyms

N/A

Synonyms

N/A

Smiles

O=C([O-])[C@H](C)C[C@H](NC(CCC([O-])=O)=O)CC1=CC=C(C2=CC=CC=C2)C=C1.[Na+].[Na+]

InChI

InChI=1S/C22H25NO5.2Na/c1-15(22(27)28)13-19(23-20(24)11-12-21(25)26)14-16-7-9-18(10-8-16)17-5-3-2-4-6-17;;/h2-10,15,19H,11-14H2,1H3,(H,23,24)(H,25,26)(H,27,28);;/q;2*+1/p-2/t15-,19+;;/m1../s1

Description

Disodium (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-(3-carboxypropanamido)-2-methylvalerate is an isolate-level impurity characterized by a biphenyl aromatic core and an ionizable carboxylate function that imparts amphiphilic behavior and enhanced aqueous solubility as a sodium salt. Its defined 2R,4S stereochemistry can give rise to stereochemical and positional analogues during synthesis, affecting purity and potency of target material. Analytical identification and quantification are typically achieved by HPLC with UV detection, LC-MS for accurate mass confirmation, and 1H/13C NMR for structural assignment. Controlling formation via optimized coupling conditions, purification and counterion exchange is recommended to meet impurity specifications and minimize downstream impact.