Docetaxel EP Impurity A
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Includes: HPLC, MASS/LC-MS, 1H NMR, FT-IR, Potency, Structure Elucidation Report (SER), and additional analytical data depending on the product.

1887057-05-7Docetaxel EP Impurity A

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Catalogue No.:VL49007
CAS No.:1887057-05-7
Mol. Formula:C41H55NO14
Mol. Weight:785.88 g/mol

Additional information on CAS 1887057-05-7

Parent drug

Docetaxel Trihydrate

IUPAC Name

5β, 20-Epoxy-1, 7β, 10β-trihydroxy-9-oxotax-11-ene-2α, 4, 13α-triyl 4-acetate 13-[(2R, 3S)-3-[[(1, 1-dimethylethoxy)carbonyl]amino]-2-hydroxy-3-phenyl propanoate] 2-[(2E)-2-methylbut-2-enoate]

Synonyms

2-Debenzoxyl 2-pentenoyl docetaxel

Description

Docetaxel EP Impurity A (CAS No.: 1887057-05-7) or 2-Debenzoxyl 2-pentenoyl docetaxel is an adulteration of Docetaxel which is a member of the taxoid class of antineoplastic agents. It depicts its action by bettering the microtubule assembly and by stabilizing microtubules by preventing their depolymerization and thereby disrupting normal cell division.

References

Vasu Dev, R., et al. “Isolation and Characterization of Impurities in Docetaxel.” Journal of Pharmaceutical and Biomedical Analysis, vol. 40, no. 3, Feb. 2006, pp. 614–22, https://doi.org/10.1016/j.jpba.2005.10.037.?Fulton, Bret, and Caroline M. Spencer. “Docetaxel.” Drugs, vol. 51, no. 6, June 1996, pp. 1075–92, https://doi.org/10.2165/00003495-199651060-00011.

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