Docetaxel EP Impurity C
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Includes: HPLC, MASS/LC-MS, 1H NMR, FT-IR, Potency, Structure Elucidation Report (SER), and additional analytical data depending on the product.

153381-68-1Docetaxel EP Impurity C

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Catalogue No.:VL49002
CAS No.:153381-68-1
Mol. Formula:C43H53NO14
Mol. Weight:807.88 g/mol

Additional information on CAS 153381-68-1

Parent drug

Docetaxel Trihydrate

IUPAC Name

(2b, 5b, 7a, 10b, 13a)-4-Acetoxy-13-(((2R, 3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoyl)oxy)-1, 7, 10-trihydroxy-9-oxo-5, 20-epoxytax-11-en-2-yl Benzoate;

Synonyms

4-Epidocetaxel / 7-Epi-Taxotere

Description

Docetaxel EP Impurity C (CAS No.: 153381-68-1) or 4-Epidocetaxel is a potent anti-cancer compound and a metabolite of Docetaxel which is an efficacious compound in the treatment of patients with metastatic breast cancer after collapsing of prior chemotherapy. Although docetaxel is accompanied by neutropenia and other adverse effects, it is a well-tolerated and safe medication for breast cancer.

References

Mavroudis, D., et al. “Front-Line Treatment of Advanced Breast Cancer with Docetaxel and Epirubicin: A Multicenter Phase II Study.” Annals of Oncology, vol. 11, no. 10, Oct. 2000, pp. 1249–54, https://doi.org/10.1023/a:1008351310818.??Lyseng-Williamson, Katherine A., and Caroline Fenton. “Docetaxel.” Drugs, vol. 65, no. 17, 2005, pp. 2513–31, https://doi.org/10.2165/00003495-200565170-00007.

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