Donepezil Open Ring Impurity
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Includes: HPLC, MASS/LC-MS, 1H NMR, FT-IR, Potency, Structure Elucidation Report (SER), and additional analytical data depending on the product.

197010-25-6Donepezil Open Ring Impurity

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Catalogue No.:VL173001
CAS No.:197010-25-6
Mol. Formula:C₂₄H₂₉NO₅
Mol. Weight:411.49 g/mol

Additional information on CAS 197010-25-6

Parent drug

Donepezil

IUPAC Name

2-(3-(1-Benzylpiperidin-4-yl)-2-oxopropyl)-4, 5-dimethoxybenzoic Acid

Pharmacopoeial Synonyms

N/A

Other Synonyms

Donepezil Open-Ring Keto Acid; 4, 5-Dimethoxy-2-[2-oxo-3-[1-(phenylmethyl)-4-piperidinyl]propyl]benzoic Acid

Smiles

Smiles-COC1=C(C=C(C(=C1)CC(=O)CC2CCN(CC2)CC3=CC=CC=C3)C(=O)O)OC

InChI

InChI-InChI=1S/C24H29NO5/c1-29-22-14-19(21(24(27)28)15-23(22)30-2)13-20(26)12-17-8-10-25(11-9-17)16-18-6-4-3-5-7-18/h3-7,14-15,17H,8-13,16H2,1-2H3,(H,27,28)

Description

Donepezil Open Ring Impurity (CAS No: 197010-25-6) or 2-(3-(1-Benzylpiperidin-4-yl)-2-oxopropyl)-4,5-dimethoxybenzoic Acid is process related impurity of Donepezil Hydrochloride drug which inhibits acetylcholine esterase, used for the treatment of Alzheimer’s disease.

References

Sreelatha, P., et al. “Impurity Profiling for Donepzil Hydrochloride Tablet Formulations and Characterisation of Potential Degradant.” Am. J. PharmTech Res 6 (2016): 213-229.

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