N-Nitroso Duloxetine Impurity (Mixture of Diastereomer)
Also known as Duloxetine Nitroso Impurity, it is one of impurity present in Duloxetine, Duloxetine is a dual serotonin and norepinephrine reuptake inhibitor, Increased serotonin and norepinephrine concentrations lead to increased activation of 5-HT2, 5-HT3, and α1 adrenergic receptors. 5-HT2 and α1 are both Gq coupled and their activation increases the activity of the inositol phospholipase C (IP3/PLC) pathway.16 This pathway leads to the release of intracellular calcium stores, increasing intracellular calcium concentrations and facilitating neuronal excitability. 5HT3 functions as a ligand-gated sodium channel, which allows sodium to flow into the neuron when activated. The increased flow of sodium into the neuron contributes to depolarization and activation of voltage-gated channels.
Additional information on Duloxetine Nitroso Impurity
VE007668
N/A
C18H18N2O2S
326.41 g/mol
Duloxetine
(S)-N-methyl-N-(3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propyl)nitrous amide
Duloxetine Nitroso Impurity
CN(N=O)CCC(OC1=C2C(C=CC=C2)=CC=C1)C3=CC=CS3
Ball, S., Desaiah, D., Zhang, Q., Thase, M., & Perahia, D. (2013). Efficacy and safety of duloxetine 60 mg once daily in major depressive disorder: a review with expert commentary. Drugs in Context, 1–16. https://doi.org/10.7573/dic.212245
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