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1620758-31-7Empagliflozin R-Furanose
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| Catalogue No.: | VE006577 |
|---|---|
| CAS No.: | 1620758-31-7 |
| Mol. Formula: | C23H27ClO7 |
| Mol. Weight: | 450.91 g/mol |
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Additional information on CAS 1620758-31-7
Parent drug
EmpagliflozinIUPAC Name
(2R,3R,4R,5R)-2-(4-Chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-5-((R)-1,2-dihydroxyethyl)tetrahydrofuran-3,4-diolSynonyms
N/ADescription
Empagliflozin R-Furanose, CAS 1620758-31-7, is a structural isomeric impurity of the sodium-glucose cotransporter 2 inhibitor empagliflozin arising from carbohydrate ring isomerization to the furanose form. With molecular formula C23H27ClO7 and molecular weight 450.91 g/mol, it retains the chlorophenyl and aryl glucoside motifs but presents altered stereoelectronic topology relative to the therapeutic pyranose scaffold. Such an impurity is typically monitored during synthetic route development and stability assessment by LC-MS/MS and high-resolution LC-MS, with orthogonal confirmation by NMR and HPLC using chiral or reversed-phase separation, due to its close physicochemical similarity to the parent drug.References
Wanner, Christoph, et al. “Empagliflozin and Progression of Kidney Disease in Type 2 Diabetes.†New England Journal of Medicine, vol. 375, no. 4, July 2016, pp. 323–34, https://doi.org/10.1056/nejmoa1515920. ?Frampton, James E. “Empagliflozin: A Review in Type 2 Diabetes.†Drugs, vol. 78, no. 10, June 2018, pp. 1037–48, https://doi.org/10.1007/s40265-018-0937-z. ?Request a Quote
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