1238210-10-0: Emtricitabine Carboxylic Acid Impurity
Emtricitabine Carboxylic Acid Impurity (CAS No.1238210-10-0) or (2R,5S)-5-(4-Amino-5-fluoro-2-oxo-1(2H)-pyrimidinyl)-1,3-oxathiolane-2-carboxylic Acid. Emtricitabine is a nucleoside reverse transcriptase inhibitor (NRTI) in combination with other antiviral agents it shows activity against HIV. It is approved for use in combination therapy.
Additional information on CAS 1238210-10-0
VL54002
1238210-10-0
C₈H₈FN₃O₄S
261.23
Emtricitabine
5-(4-Amino-5-Fluoro-2-oxo-2H-pyrimidin-1-yl)-[1,3]-oxathiolane-2-carboxylic acid
Emtricitabine IP Impurity A; (2R, 5S)-5-(4-Amino-5-fluoro-2-oxo-1(2H)-pyrimidinyl)-1, 3-oxathiolane-2-carboxylic Acid;
Bang, Lynne M., and Lesley J. Scott. “Emtricitabine.” Drugs, vol. 63, no. 22, 2003, pp. 2413–24, https://doi.org/10.2165/00003495-200363220-00003. Sax, Paul E., et al. “Coformulated Bictegravir, Emtricitabine, and Tenofovir Alafenamide versus Dolutegravir with Emtricitabine and Tenofovir Alafenamide, for Initial Treatment of HIV-1 Infection (GS-US-380–1490): A Randomised, Double-Blind, Multicentre, Phase 3, Non-Inferiority Trial.” The Lancet, vol. 390, no. 10107, Nov. 2017, pp. 2073–82, https://
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