Flucloxacillin EP Impurity E
Flucloxacillin EP Impurity E is of particular effectiveness against Gram-positive organisms in the skin and soft tissue infections, with the exception of those brought on by methicillin-resistant staphylococcus aureus (MRSA). Flucloxacillin prevents the third and final stage of bacterial cell wall formation by attaching to certain penicillin-binding proteins (PBPs) present inside the bacterial cell wall. Bacterial cell wall autolytic enzymes like autolysins then mediate cell lysis; it’s likely that flucloxacillin interacts with an autolysin inhibitor.
(2S, 5R, 6R)-6-[[[(2S, 5R, 6R)-6-[[[3-(2-chloro-6-fluorophenyl)-5-methyl-1, 2-oxazol-4-yl]carbonyl]amino]-3, 3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]hept-2-yl]carbonyl]amino]-3, 3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
Francis, Nick A., et al. “Understanding Flucloxacillin Prescribing Trends and Treatment Non-Response in UK Primary Care: A Clinical Practice Research Datalink (CPRD) Study.” Journal of Antimicrobial Chemotherapy, vol. 71, no. 7, Apr. 2016, pp. 2037–46, https://doi.org/10.1093/jac/dkw084.