951694-73-8: Methyl ester of Obeticholic acid
Methyl ester of Obeticholic acid is a synthetic bile acid and has complementary mechanisms of action, this acid is a farnesoid X receptor (FXR) agonist that is active in a wide variety of pathways, it decreases bile acid synthesis, resulting in less buildup of toxic bile acids and less cholestatic damage.
Additional information on CAS 951694-73-8
VL7730001
951694-73-8
C27H46O4
434.65
Obeticholic
(R)-Methyl 4-((3R,5S,6R,7R,8S,9S,10S,13R,14S,17R)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-hexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoate
Methyl 3?, 7-dihydroxy-6-ethyl-5?-cholanate; 6-Ethyl-3, 7-dihydroxy Methyl Ester Cholan-24-oic Acid
He, Xiao-Long, et al. “A Facile Synthesis of Ursodeoxycholic Acid and Obeticholic Acid from Cholic Acid.” Steroids, vol. 140, Dec. 2018, pp. 173–78, https://doi.org/10.1016/j.steroids.2018.10.009. Brown, Robert S. “Use of Obeticholic Acid in Patients with Primary Biliary Cholangitis.” Gastroenterology & Hepatology, vol. 14, no. 11, Millennium Medical Publishing, 2018, pp. 654–57, http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284343/.
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