190078-45-6: Montelukast EP impurity A(sodium salt)

Montelukast EP impurity A (sodium salt) (CAS No: 190078-45-6) or Montelukast Sodium (S)-Isomer is an impurity present in montelukast which is used for the inhibition of the human drug-metabolizing enzyme cytochrome P4502C8. It was demonstrated to be a potent inhibitor of CYP2C8-catalyzed in human liver microsomes.

Additional information

Catalogue No.

VE006811

CAS No.

190078-45-6

Molecular Formula

C35H35ClNNaO3S

Molecular Weight

608.17

IUPAC Name

1-[[[(1S)-1-[3-[(1E)-2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropaneacetic acid sodium salt

Synonyms

Montelukast Sodium (S)-Isomer/ ent-Montelukast (Sodium Salt)

References

Tiwari, Shobhit Kumar, et al. “Study of Degradation Behaviour of Montelukast Sodium and Its Marketed Formulation in Oxidative and Accelerated Test Conditions and Prediction of Physicochemical and ADMET Properties of Its Degradation Products Using ADMET PredictorTM.” Journal of Pharmaceutical and Biomedical Analysis, vol. 158, Sept. 2018, pp. 106–18, https://doi.org/10.1016/j.jpba.2018.05.040. ?Walsky, Robert L., et al. “SELECTIVE INHIBITION of HUMAN CYTOCHROME P4502C8 by MONTELUKAST.” Drug Meta

Status

In-stock