1187586-61-3: Montelukast EP Impurity D

Montelukast EP Impurity D (CAS No: 1187586-61-3) or Montelukast Related Compound C is an impurity present in montelukast which is used in the treatment of steroid-dependent eosinophilic gastroenteritis. It is also utilized in the treatment of Eosinophilic oesophagitis.

Additional information

Catalogue No.

VE006805

CAS No.

1187586-61-3

Molecular Formula

C41H46ClNO5S2

Molecular Weight

732.39

IUPAC Name

1-[[[(1R)-1-[3-[(1R)-1-[[[1-(Carboxymethyl)cyclopropyl]methyl]thio]-2-(7-chloro-2-quinolinyl)ethyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl) phenyl] propyl] thio]methyl]-cyclopropaneacetic acid

Synonyms

Montelukast Related Compound C/ Montelukast Michael Adduct (R, R)-Isomer/ Montelukast Bis-Sulfide (Mixture of Diastereomers)

References

Emerce, Esra, et al. “Determination of the Impurities in Drug Products Containing Montelukast and in Silico/in Vitro Genotoxicological Assessments of Sulfoxide Impurity.” Toxicology Letters, vol. 238, no. 2, Oct. 2015, pp. 90–99, https://doi.org/10.1016/j.toxlet.2015.07.003. ?Attwood, S. E. A. “Eosinophilic Oesophagitis: A Novel Treatment Using Montelukast.” Gut, vol. 52, no. 2, Feb. 2003, pp. 181–85, https://doi.org/10.1136/gut.52.2.181. ?

Status

In-stock