Moxifloxacin EP Impurity E (2HCl)
Also known as Moxifloxacin Related Compound E or Moxifloxacin O-Desmethyl Analog, it is one of impurity present in Moxifloxacin, the bactericidal action of moxifloxacin results from the inhibition of the enzymes topoisomerase II and topoisomerase IV. DNA gyrase is an essential enzyme that is involved in the replication and repair of bacterial DNA. Topoisomerase IV is an enzyme that acts on the partitioning of the chromosomal DNA during bacterial cell division. which is used in the treatment of sinus and lung infections such as sinusitis, pneumonia, and secondary infections in chronic bronchitis.
Additional information on Moxifloxacin EP Impurity E (2HCl)
1-Cyclopropyl-6-fluoro-8-hydroxy-7-[(4aS, 7aS)-octahydro-6H-pyrrolo [3, 4-b]pyridin-6-yl]-4-oxo-1, 4-dihydroquinoline-3-carboxylic acid dihydrochloride
Moxifloxacin Related Compound E / Moxifloxacin O-Desmethyl Analog
Tulkens, P. M., Arvis, P., & Kruesmann, F. (2012). Moxifloxacin Safety. Drugs in R&D, 12(2), 71–100. https://doi.org/10.2165/11634300-000000000-00000
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