Additional information on N-methyl-N-nitrosopropane-1 | 3-diamine
Parent drug
Nitroso inhouse impurity
IUPAC Name
N-methyl-N-nitrosopropane-1,3-diamine
Synonyms
N/A
Smiles
NCCCN(C)N=O
InChI
InChI=1S/C4H11N3O/c1-7(6-8)4-2-3-5/h2-5H2,1H3
Description
N-methyl-N-nitrosopropane-1,3-diamine is a nitrosamine impurity with the molecular formula C4H11N3O and molecular weight 117.09 g/mol. Structurally, it contains an N-nitroso functional group on a secondary amine framework, a motif associated with metabolic activation to electrophilic species and consequent genotoxic concern under ICH M7 principles. Such compounds may arise during nitrosating conditions in synthesis, processing, or storage when amine precursors encounter nitrite. Trace-level determination generally requires GC-MS or LC-MS/MS, often with selective ion monitoring and isotopically labeled internal standards because of low volatility and strong matrix effects.
To provide the best experiences, we use technologies like cookies to store and/or access device information. Consenting to these technologies will allow us to process data such as browsing behavior or unique IDs on this site. Not consenting or withdrawing consent, may adversely affect certain features and functions.
Functional
Always active
The technical storage or access is strictly necessary for the legitimate purpose of enabling the use of a specific service explicitly requested by the subscriber or user, or for the sole purpose of carrying out the transmission of a communication over an electronic communications network.
Preferences
The technical storage or access is necessary for the legitimate purpose of storing preferences that are not requested by the subscriber or user.
Statistics
The technical storage or access that is used exclusively for statistical purposes.The technical storage or access that is used exclusively for anonymous statistical purposes. Without a subpoena, voluntary compliance on the part of your Internet Service Provider, or additional records from a third party, information stored or retrieved for this purpose alone cannot usually be used to identify you.
Marketing
The technical storage or access is required to create user profiles to send advertising, or to track the user on a website or across several websites for similar marketing purposes.
To provide the best experiences, we use technologies like cookies to store and/or access device information. Consenting to these technologies will allow us to process data such as browsing behavior or unique IDs on this site. Not consenting or withdrawing consent, may adversely affect certain features and functions.
Functional
Always active
The technical storage or access is strictly necessary for the legitimate purpose of enabling the use of a specific service explicitly requested by the subscriber or user, or for the sole purpose of carrying out the transmission of a communication over an electronic communications network.
Preferences
The technical storage or access is necessary for the legitimate purpose of storing preferences that are not requested by the subscriber or user.
Statistics
The technical storage or access that is used exclusively for statistical purposes.The technical storage or access that is used exclusively for anonymous statistical purposes. Without a subpoena, voluntary compliance on the part of your Internet Service Provider, or additional records from a third party, information stored or retrieved for this purpose alone cannot usually be used to identify you.
Marketing
The technical storage or access is required to create user profiles to send advertising, or to track the user on a website or across several websites for similar marketing purposes.
