100% accuracy
of data
of data
24/7 scientific
support
support
0% tolerance in
quality of product
quality of product
Stock Locations
- New Jersey, USA
- Czech Republic, EU
- Mumbai, India
* Stock subject to availability.
Documentation
Includes: HPLC, MASS/LC-MS, 1H NMR, FT-IR, Potency, Structure Elucidation Report (SER), and additional analytical data depending on the product.
66505-80-4N-Nitroso Diclofenac
● In Stock
| Catalogue No.: | VE009623 |
|---|---|
| CAS No.: | 66505-80-4 |
| Mol. Formula: | C14H10Cl2N2O3 |
| Mol. Weight: | 325.15 g/mol |
Order Online
Additional information on CAS 66505-80-4
Parent drug
DiclofenacIUPAC Name
2-[(2,6-Dichlorophenyl)nitrosoamino]benzeneacetic AcidPharmacopeial Synonyms
N/ASynonyms
2-[2-(2,6-Dichloro-N-nitrosoanilino)phenyl]acetic acidSmiles
O=C(O)CC1=CC=CC=C1N(C2=C(Cl)C=CC=C2Cl)N=OInChI
InChI=1S/C14H10Cl2N2O3/c15-10-5-3-6-11(16)14(10)18(17-21)12-7-2-1-4-9(12)8-13(19)20/h1-7H,8H2,(H,19,20)FDA Potency Category 5 NDSRI
1500 ng/day is the U.S. FDA’s current Acceptable Intake (AI) limit for N-nitroso-diclofenac (NDSRI). Refer to the FDA nitrosamine page for the latest guidance.Description
N-Nitroso Diclofenac (CAS 66505-80-4) is a nitrosamine-related impurity derived from diclofenac, formally identified as 2-[2-(2,6-Dichloro-N-nitrosoanilino)phenyl]acetic acid. With molecular formula C14H10Cl2N2O3 and molecular weight 325.15 g/mol, it contains an N-nitroso arylamine moiety associated with potential genotoxic concern under ICH M7 principles. Formation may arise during nitrosating conditions, residual nitrite exposure, or oxidative degradation pathways involving the parent secondary amine functionality. Structural elucidation and trace-level quantification typically require LC-MS/MS, high-resolution mass spectrometry, and, where volatility permits, GC-MS confirmation, with careful control of ion suppression and isomeric interferences.Request a Quote
"*" indicates required fields
Other products related to Diclofenac and Nitroso impurities
Impurity structure
Parent Drug Name
CAS No.
Name of Impurity
Catalog No.
Diclofenac
CAS No. N/A
Cat No. VE0010352
