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Includes: HPLC, MASS/LC-MS, 1H NMR, FT-IR, Potency, Structure Elucidation Report (SER), and additional analytical data depending on the product.

10595-95-6N-Nitrosomethylethylamine (NMEA)

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Catalogue No.:	VE006114
CAS No.:	10595-95-6
Mol. Formula:	C3H8N2O
Mol. Weight:	88.11 g/mol

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Additional information on CAS 10595-95-6

Parent drug

Nitroso inhouse impurity

IUPAC Name

N-Methyl-N-nitrosoethanamine

Pharmacopoeial Synonyms

N/A

Other Synonyms

Ethylmethylnitrosamine; Methylethylnitrosamine; N-Nitroso-N-methylethylamine; N,N-Methylethylnitrosamine; N-methyl-N-nitroso-ethanamine

Smiles

CCN(C)N=O

InChI

InChI=1S/C3H8N2O/c1-3-5(2)4-6/h3H2,1-2H3

Shipping Condition

Ambient Temperature

Characterization Data (Included)

HPLC, MASS/LC-MS, 1H NMR, FT-IR, Potency, and Structure Elucidation Report (SER).

Additional Characterization Data

QNMR, D2O Exchange, 13C NMR, 13C APT, COSY NMR, NOESY NMR, 15N NMR, HSQC NMR, HMQC NMR, and HMBC NMR. These are available upon request and may be free or subject to additional charges.

Description

N-Nitrosoethylmethylamine (NMEA), CAS 10595-95-6, is a low-molecular-weight nitrosamine with the molecular formula C3H8N2O and molecular weight 88.11 g/mol. It is structurally related to the N-nitrosodialkylamine class, a group of compounds of toxicological concern because of established genotoxic and carcinogenic potential. NMEA may arise as a process-related impurity from nitrosation of secondary amine precursors under acidic and nitrite-rich conditions, or from cross-contamination in amine-containing manufacturing streams. Trace-level determination typically requires highly selective methods such as LC-MS/MS or GC-MS, often with careful control of background contamination and thermal instability.

References

von Hofe, Eric, et al. “v-Deuteration of N-Nitrosoethylmethylamine Causes a Shift in DNA Methylation from Rat Liver to Esophagus.” Carcinogenesis, vol. 12, no. 4, 1991, pp. 545–49, https://doi.org/10.1093/carcin/12.4.545.?