Niflumic Acid EP Impurity E (CAS 15871-46-2) | also known as 6-[m-(Trifluoromethyl)anilino]nicotinic acid or 6-((3-(Trifluoromethyl)phenyl)amino)nicotinic acid | is a structurally characterized process-related impurity detected in niflumic acid manufacture. This aromatic nicotinic acid derivative exhibits increased lipophilicity from the trifluoromethyl-substituted aniline moiety and shows distinctive reversed-phase HPLC retention and LC-MS fragmentation consistent with anilino loss. Analytical control emphasizes validated chromatographic methods | retention time and mass confirmation | and assessment of hydrolytic stability. Routine monitoring of Impurity E supports accurate impurity profiling | specification setting and maintenance of API quality.
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