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Includes: HPLC, MASS/LC-MS, 1H NMR, FT-IR, Potency, Structure Elucidation Report (SER), and additional analytical data depending on the product.

O-Dealkylated Belumosudil Sulfate

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Catalogue No.:	VE0025751
CAS No.:	N/A
Mol. Formula:	C21H17N5O5S
Mol. Weight:	451.46 g/mol

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Additional information on

Parent drug

Belumosudil

IUPAC Name

3-(4-((1H-Indazol-5-yl)amino)quinazolin-2-yl)phenol Sulfate

Synonyms

N/A

Smiles

OC1=CC=CC(C2=NC(NC3=CC4=C(NN=C4)C=C3)=C5C=CC=CC5=N2)=C1.O=S(O)(O)=O

InChI

InChI=1S/C21H15N5O.H2O4S/c27-16-5-3-4-13(11-16)20-24-19-7-2-1-6-17(19)21(25-20)23-15-8-9-18-14(10-15)12-22-26-18;1-5(2,3)4/h1-12,27H,(H,22,26)(H,23,24,25);(H2,1,2,3,4)

Description

O-Dealkylated Belumosudil Sulfate impurity represents a primary dealkylation product of belumosudil synthesis or metabolic conversion. This polar sulfate derivative exhibits altered physicochemical properties including increased polarity and reduced lipophilicity, impacting chromatographic retention and extraction recovery. Analytical characterization requires LC-MS and NMR to confirm mass shift and site of O-dealkylation, and qualified HPLC methods are recommended for quantitation in drug substance and formulated products. Control strategy should address formation during alkylation, hydrolysis, or sulfation steps and include stability studies, impurity profiling, identification thresholds and validated limits to meet regulatory expectations for safety and quality.