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147663-30-7Albuterol Related Compound E (Free Base)

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Catalogue No.:	VE0019620
CAS No.:	147663-30-7
Mol. Formula:	C26H40N2O5
Mol. Weight:	460.61 g/mol

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Additional information on CAS 147663-30-7

Parent drug

Salbutamol

IUPAC Name

2,2′-oxybis(methylene)bis{4-[2-(tert-butylamino)-1-hydroxyethyl]phenol}

Pharmacopeial Synonyms

Salbutamol EP Impurity F; Salbutamol BP Impurity F

Synonyms

Salbutamol Dimer Ether

Smiles

OC1=CC=C(C(O)CNC(C)(C)C)C=C1COCC2=CC(C(O)CNC(C)(C)C)=CC=C2O

InChI

InChI=1S/C26H40N2O5/c1-25(2,3)27-13-23(31)17-7-9-21(29)19(11-17)15-33-16-20-12-18(8-10-22(20)30)24(32)14-28-26(4,5)6/h7-12,23-24,27-32H,13-16H2,1-6H3

Description

Albuterol Related Compound E, also designated Salbutamol EP Impurity F, Salbutamol BP Impurity F, or Salbutamol Dimer Ether, is a dimeric ether impurity of the phenylethanolamine bronchodilator salbutamol. CAS 147663-30-7 identifies the free base with molecular formula C26H40N2O5 and molecular weight 460.61 g/mol. Its structure reflects oxidative or process-related etherification between salbutamol-derived phenolic functionalities, rather than a primary degradant class such as a nitrosamine. Owing to its close physicochemical similarity to the parent drug, separation commonly relies on reversed-phase LC with UV and LC-MS/MS confirmation, and, where trace-level profiling is required, high-resolution mass spectrometry is often employed.