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Sertraline Tetralone Racemate
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Documentation

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Includes: HPLC, MASS/LC-MS, 1H NMR, FT-IR, Potency, Structure Elucidation Report (SER), and additional analytical data depending on the product.

79560-19-3Sertraline Tetralone Racemate

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Catalogue No.:VE008994
CAS No.:79560-19-3
Mol. Formula:C16H12Cl2O
Mol. Weight:291.2 g/mol

Additional information on CAS 79560-19-3

Parent drug

Sertraline

IUPAC Name

4-(3,4-Dichlorophenyl)-1-tetralone

Pharmacopeial Synonyms

N/A

Synonyms

4-(3,4-dichlorophenyl)-3,4-dihydro-1(2H)-naphthalenone; 4-(3,4-dichlorophenyl)tetralin-1-one

Smiles

O=C1CCC(C2=CC=C(Cl)C(Cl)=C2)C3=C1C=CC=C3

InChI

InChI=1S/C16H12Cl2O/c17-14-7-5-10(9-15(14)18)11-6-8-16(19)13-4-2-1-3-12(11)13/h1-5,7,9,11H,6,8H2

Shipping Condition

Ambient Temperature

Description

Sertraline Tetralone Racemate (CAS 79560-19-3), also known as 4-(3,4-dichlorophenyl)-3,4-dihydro-1(2H)-naphthalenone or 4-(3,4-dichlorophenyl)tetralin-1-one, is a stereoisomeric impurity encountered in sertraline manufacture. As a tetralone intermediate, it can persist due to incomplete reduction or racemization during synthesis and affects enantiomeric purity, residual solvent profile, and downstream crystallization behavior. Accurate identification and quantification by HPLC, chiral HPLC, LC-MS and NMR are essential for impurity profiling and specification setting in accordance with ICH guidelines. Removal is typically achieved through optimized reaction control, targeted purification by chromatography or recrystallization, and validation of analytical methods to ensure batch consistency.

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