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Includes: HPLC, MASS/LC-MS, 1H NMR, FT-IR, Potency, Structure Elucidation Report (SER), and additional analytical data depending on the product.

Simvastatin-D6 Hydroxy Acid (Ammonium Salt)

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Catalogue No.:	DVE002082
CAS No.:	N/A
Mol. Formula:	C25H43NO6
Mol. Weight:	459.6 g/mol

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Additional information on

Parent drug

Simvastatin

IUPAC Name

(ssR,dR,1S,2S,6R,8S,8aR)-8-[2,2-(Dimethyl-d6)-1-oxobutoxy]-1,2,6,7,8,8a-hexahydro-ss,d-dihydroxy-2,6-dimethyl-1-naphthaleneheptanoic Acid Ammonium Salt

Pharmacopeial Synonyms

N/A

Synonyms

N/A

Smiles

O=C(C(CC)(C([2H])([2H])[2H])C([2H])([2H])[2H])O[C@H]1C[C@@H](C)C=C2[C@@]1([H])[C@@H](CC[C@H](O)C[C@@H](CC([O-])=O)O)[C@@H](C)C=C2

InChI

InChI=1S/C25H40O6/c1-6-25(4,5)24(30)31-21-12-15(2)11-17-8-7-16(3)20(23(17)21)10-9-18(26)13-19(27)14-22(28)29/h7-8,11,15-16,18-21,23,26-27H,6,9-10,12-14H2,1-5H3,(H,28,29)/p-1/t15-,16-,18-,19-,20-,21-,23-/m0/s1/i4D3,5D3

Description

Simvastatin-D6 Hydroxy Acid (Ammonium Salt) is a deuterated impurity standard used for impurity profiling of simvastatin hydrolytic degradation products. As the D6-labeled hydroxy acid ammonium salt it provides a predictable mass shift of +6 Da enabling selective detection and accurate quantitation by LC-MS and GC-MS methods. The compound typically appears as a polar, hygroscopic ammonium salt with good solubility in aqueous methanol and requires cold storage to maintain isotopic integrity. Its defined isotopic pattern and chromatographic retention make it indispensable for method validation, forced degradation studies, and limit testing where precise measurement of simvastatin hydrolysis is critical.