Thiamazole EP Impurity C, also known as Methimazole Related Compound C, is the sulfur-containing imidazole derivative methimazole (CAS 14486-52-3), with molecular formula C5H8N2S and molecular weight 128.2 g/mol. Structurally, it belongs to the thioimidazole class and is commonly associated with synthetic route impurities or degradation-related transformation products of thiamazole. Its heteroaromatic, basic, and sulfur-rich framework necessitates orthogonal characterization by LC-MS/MS, HPLC with UV detection, and, where required, NMR confirmation. Within regulatory impurity profiling, such species are evaluated for trace-level presence and potential relevance under ICH impurity control principles.
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