Tigecycline Related Compound B
It is an impurity present in Tigecycline. Tigecycline is a glycylcycline antibiotic, that inhibits protein translation in bacteria by binding to the 30S ribosomal subunit and blocking the entry of amino-acyl tRNA molecules into the A site of the ribosome. which prevents the unionization of amino acid residues into elongating peptide chains. which carries a glycylamido moiety attached to the 9-position of minocycline. Tigecycline is not affected by the two major tetracycline resistance mechanisms ribosomal protection and efflux. which is used to treat several susceptible bacterial infections.
Additional information on Tigecycline Related Compound B
VE009861
N/A
C23H28N4O7 ? xHCl
472.50 g/mol
Tigecycline
((4S, 4aS, 5aR, 12aS)-9-Amino-4, 7-bis(dimethylamino)-3, 10, 12, 12a-tetrahydroxy-1, 11-dioxo1, 4, 4a, 5, 5a, 6, 11, 12a-octahydrotetracene-2-carboxamide hydrochloride (1:x))
N/A
Greer, N. D. (2006). Tigecycline (Tygacil): The First in the Glycylcycline Class of Antibiotics. Baylor University Medical Center Proceedings, 19(2), 155–161. https://doi.org/10.1080/08998280.2006.11928154
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