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内容: HPLC、MASS/LC-MS、1H NMR、FT-IR、含量、構造解析レポート（SER）、および製品に応じた追加分析データ。

1443421-69-9Abacavir EP Impurity B

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カタログ番号:	VL760001
CAS番号:	1443421-69-9
分子式:	C18H21ClN10O
分子量:	428.8 g/mol

見積もり依頼

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に関する追加情報 CAS 1443421-69-9

親薬物

Abacavir

IUPAC名

6-(Cyclopropylamino)-9-[(1R, 4S)-4-[[(2, 5-diamino-6-chloropyrimidin-4-yl)oxy]methyl]cyclopent-2-enyl]-9H-purine-2-amine

薬局方同義語

O-Pyrimidine Derivative Abacavir; Abacavir Related Compound D

Other Synonyms

Abacavir 5′-4-Chloro-6-methylpyrimidine-2,5-diamine; 6-N-cyclopropyl-9-[(1R,4S)-4-[(2,5-diamino-6-chloropyrimidin-4-yl)oxymethyl]cyclopent-2-en-1-yl]purine-2,6-diamine; N6-Cyclopropyl-9-((1R,4S)-4-(((2,5-diamino-6-chloropyrimidin-4-yl)oxy)methyl)cyclopent-2-en-1-yl)-9H-purine-2,6-diamine; N6-Cyclopropyl-9-((1R,4S)-4-((2,5-diamino-6-chloropyrimidin-4-yloxy)methyl)cyclopent-2-enyl(-9H-purine-2,6 diamine; 9H-PURINE-2,6-DIAMINE, N6-CYCLOPROPYL-9-((1R,4S)-4-(((2,5-DIAMINO-6-CHLORO-4-PYRIMIDINYL)OXY)METHYL)-2-CYCLOPENTEN-1-YL)-

SMILES

NC1=NC(NC2CC2)=C3N=CN([C@H]4C=C[C@@H](COC5=NC(N)=NC(Cl)=C5N)C4)C3=N1

InChI

InChI=1S/C18H21ClN10O/c19-13-11(20)16(28-17(21)25-13)30-6-8-1-4-10(5-8)29-7-23-12-14(24-9-2-3-9)26-18(22)27-15(12)29/h1,4,7-10H,2-3,5-6,20H2,(H2,21,25,28)(H3,22,24,26,27)/t8-,10+/m1/s1

説明

Abacavir EP Impurity B (CAS No: 1443421-69-9) or Abacavir O-Pyrimidine Impurity / Abacavir Related Compound D is synthesized by degradation of Abacavir which is a nucleoside reverse transcriptase inhibitor and Its mechanism include chain termination subsequent to incorporation into the growing polynucleotide strand. It is used in the treatment of HIV infection.

References

Kurmi, Moolchand, et al. “Stability Behaviour of Antiretroviral Drugs and Their Combinations. 5: Characterization of Novel Degradation Products of Abacavir Sulfate by Mass and Nuclear Magnetic Resonance Spectrometry.” Journal of Pharmaceutical and Biomedical Analysis, vol. 134, Feb. 2017, pp. 372–84, https://doi.org/10.1016/j.jpba.2016.10.019. ?Vukkum, Pallavi. “Stress Degradation Behavior of Abacavir Sulfate and Development of a Suitable Stability-Indicating UHPLC Method for the Determination