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内容: HPLC、MASS/LC-MS、1H NMR、FT-IR、含量、構造解析レポート（SER）、および製品に応じた追加分析データ。

2206825-87-6Apixaban Amino Acid Impurity

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カタログ番号:	VL3170013
CAS番号:	2206825-87-6
分子式:	C25H27N5O5
分子量:	477.52 g/mol

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に関する追加情報 CAS 2206825-87-6

親薬物

Apixaban

IUPAC名

5-((4-(3-carbamoyl-1-(4-methoxyphenyl)-7-oxo-1, 4, 5, 7-tetrahydro-6H-pyrazolo[3, 4-c]pyridin-6-yl)phenyl)amino)pentanoic acid

薬局方同義語

N/A

Other Synonyms

Apixaban Open Ring Impurity; Apixaban Open Chain Acid Impurity; 5-[[4-[3-(Aminocarbonyl)-1,4,5,7-tetrahydro-1-(4-methoxyphenyl)-7-oxo-6H-pyrazolo[3,4-c]pyridin-6-yl]phenyl]amino]pentanoic Acid; 5-({4-[3-carbamoyl-1-(4-methoxyphenyl)-7-oxo-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridin-6-yl]phenyl}amino)pentanoic acid

SMILES

O=C(N(C1=CC=C(NCCCCC(O)=O)C=C1)CC2)C3=C2C(C(N)=O)=NN3C4=CC=C(OC)C=C4

InChI

InChI=1S/C25H27N5O5/c1-35-19-11-9-18(10-12-19)30-23-20(22(28-30)24(26)33)13-15-29(25(23)34)17-7-5-16(6-8-17)27-14-3-2-4-21(31)32/h5-12,27H,2-4,13-15H2,1H3,(H2,26,33)(H,31,32)

説明

Apixaban Amino Acid Impurity (CAS No: 2206825-87-6) or 5-((4-(3-carbamoyl-1-(4-methoxyphenyl)-7-oxo-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)phenyl)amino)pentanoic acid, it produces its antithrombotic effect by inhibiting free and clot-bound factor Xa and is used as Treatment And Prevention of Thromboembolic Disease.

References

Budovich, Aliaksandr, et al. “Role of Apixaban (Eliquis) in the Treatment and Prevention of Thromboembolic Disease.” Pharmacy and Therapeutics, vol. 38, no. 4, 1 Apr. 2013, pp. 206–231, www.ncbi.nlm.nih.gov/pmc/articles/PMC3684191/#b5-ptj3804206.