Mil = 5- methylene-L-isoleucine:4,10-Anhydro[N-[[(4R)-2-[(1S,2S)-1-amino-2-methylbutyl]-4,5-dihydro-1,3-thiazol-4-yl]carbonyl]-L-leucyl-D-α-glutamyl-L-isoleucyl-L-lysyl-D-ornithyl-5-methylene-L-isoleucyl-D-phenylalanyl-L-histidyl-D-α-aspartyl-L-asparagine]
Pharmacopeial Synonyms
Bacitracin J2
同義語
N/A
説明
Bacitracin EP Impurity P は Bacitracin J2 とも表記され、bacitracin 複合体に含まれる近縁の環状ドデカペプチド不純物である。主として発酵過程における生合成上の微小不均一性、ならびにその後の精製段階で生じるペプチド鎖変異に由来する。分子式 C66H103N17O16S、分子量 1422.70 g/mol を有し、bacitracin 特有の硫黄含有ペプチド骨格とチアゾリン様モチーフを保持しつつ、主成分とは配列および酸化状態の差で区別される。同定と定量には、逆相HPLC、LC-MS/MS、高分解能質量分析、ならびにペプチドマッピングとMS/MS断片解析が通常必要である。
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