Dapagliflozin Bromo Lactone Impurity or (2S,3S,4R,5R,6R)-2-(4-bromo-3-(4-ethoxybenzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol compound with (S)-propane-1,2-diol (1:1) hydrate is a impurity of Dapagliflozin. Dapagliflozin is a sodium-glucose co-transporter-2 (SGLT-2) blocker that lowers glucose levels in the blood of patients having type 2 diabetes mellitus (T2DM) by promoting glycosuria.
References
Braem, Alan, et al. “Discovery and Development of Selective Renal Sodium-Dependent Glucose Cotransporter 2 (SGLT2) Dapagliflozin for the Treatment of Type 2 Diabetes.†Topics in Medicinal Chemistry, 2014, pp. 73–94, https://doi.org/10.1007/7355_2014_41.?Wiviott, Stephen D., et al. “The Design and Rationale for the Dapagliflozin Effect on Cardiovascular Events (DECLARE)–TIMI 58 Trial.†American Heart Journal, vol. 200, June 2018, pp. 83–89, https://doi.org/10.1016/j.ahj.2018.01.012.?
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