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内容: HPLC、MASS/LC-MS、1H NMR、FT-IR、含量、構造解析レポート（SER）、および製品に応じた追加分析データ。

320-51-4Sorafenib Impurity C

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カタログ番号:	VE005960
CAS番号:	320-51-4
分子式:	C7H5ClF3N
分子量:	195.57 g/mol

見積もり依頼

RFQリストに追加

に関する追加情報 CAS 320-51-4

親薬物

Regorafenib / Sorafenib

IUPAC名

4-Chloro-3-(trifluoromethyl)-benzenamine

薬局方同義語

Regorafenib FP Impurity B/5-Amino-2-chlorobenzotrifluoride

Other Synonyms

4-Chloro-3-(trifluoromethyl)aniline)

SMILES

C1=CC(=C(C=C1N)C(F)(F)F)Cl

InChI

InChI=1S/C7H5ClF3N/c8-6-2-1-4(12)3-5(6)7(9,10)11/h1-3H,12H2

Shipping Condition

Ambient Temperature

Characterization Data (Included)

HPLC, MASS/LC-MS, 1H NMR, FT-IR, Potency, and Structure Elucidation Report (SER).

Additional Characterization Data

QNMR, D2O Exchange, 13C NMR, 13C APT, COSY NMR, NOESY NMR, 15N NMR, HSQC NMR, HMQC NMR, and HMBC NMR. These are available upon request and may be free or subject to additional charges.

説明

Also known as 5-Amino-2-chlorobenzotrifluoride or 4-Chloro-3-(trifluoromethyl)aniline, it is an impurity present in Sorafenib which is a potent oral multi-kinase inhibitor used for cancer treatment. It exhibits anti-angiogenic and anti-tumor activity by suppressing the autophosphorylation of several cell surface tyrosine kinases involved in controlling cell growth.

References

Johnsirani, P., et al. “LC-ESI-QTOF-MS Analysis Utilizing Gas-Phase Fragmentation Reactions Subjected to ESI-IS-CID and ESI-CID-MS/MS Conditions to Study the Degradation Behaviour of Sorafenib Tosylate: NMR and in Vitro Cytotoxicity and Apoptosis Detection Studies of Hydrolytic Degradation Products.” Journal of Pharmaceutical and Biomedical Analysis, vol. 177, Jan. 2020, p. 112881, https://doi.org/10.1016/j.jpba.2019.112881. ?