빌라스틴 니트로소 불순물 1, 즉 N-니트로소 빌라스틴은 2차 아민의 니트로소화에서 유래하는 니트로사민 계열의 공정 또는 분해 불순물이다. CAS 번호는 2731008-04-9이며, 분자식 C12H14N4O, 분자량 230.3 g/mol에 해당한다. 구조적 니트로사민으로서 N-니트로소 종의 DNA 반응 가능성 때문에 ICH M7에 따른 유전독성 불순물 평가와 관련된다. 초미량 수준의 검출과 정량에는 고감도 상보적 분석법이 요구되며, 특히 LC-MS/MS가 핵심적이다. 구조 확인에는 LC-HRMS가 사용되고, 휘발성이 충분한 경우 GC-MS가 보조적으로 적용된다.
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