Apixaban Related Compound F, CAS 536759-91-8은 Ethyl 1-(4-methoxyphenyl)-6-(4-nitrophenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate로, 분자식 C22H20N4O6, 분자량 436.42 g/mol의 치환된 피라졸로피리디논 불순물이다. 구조적으로 니트로방향족 아릴 치환기와 에스터화된 헤테로고리 핵심을 가지며, 이는 아픽사반 골격 형성 과정에서 발생하는 공정 유래 중간체 또는 부생성물과 일치한다. 니트로방향족 불순물은 ICH M7 관점에서 잠재적 유전독성 평가가 요구될 수 있으므로, 미량 정량은 일반적으로 LC-MS/MS, 고해상도 질량분석, 직교 HPLC에 의존하며, UV 검출만으로는 동정 특이성이 충분하지 않다.
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![5-((4-(3-carbamoyl-1-(4-methoxy phenyl)-7-oxo-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)phenyl) (nitroso) amino) pentanoic acid](https://veeprho.com/wp-content/uploads/2026/10/5-4-3-carbamoyl-1-4-methoxy-phenyl-7-oxo-1457-tetrahydro-6H-pyrazolo34-cpyridin-6-ylphenyl-nitroso-amino-pentanoic-acid-3094994-84-7-VE0012199-c227.png "5-((4-(3-carbamoyl-1-(4-methoxy phenyl)-7-oxo-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)phenyl) (nitroso) amino) pentanoic acid")
