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Documentation
포함 사항: HPLC, MASS/LC-MS, 1H NMR, FT-IR, 함량, 구조 규명 보고서(SER), 그리고 제품에 따라 추가 분석 데이터가 제공됩니다.
124752-25-6Abacavir EP Impurity C
● 재고 있음
| 카탈로그 번호: | VL760006 |
|---|---|
| CAS 번호: | 124752-25-6 |
| 분자식: | C11H14N6O |
| 분자량: | 246.27 g/mol |
에 대한 추가 정보 CAS 124752-25-6
모약물
AbacavirIUPAC명
((1S, 4R)-4-(2, 6-diamino-9H-purin-9-yl)cyclopent-2-en-1-yl)methanolPharmacopeial Synonyms
Descyclopropyl AbacavirOther Synonyms
6-Aminocarbovir; (+-)-Carbocyclic-2′,3′-dideoxydidehydro-2-6-diaminopurinenucleoside; ((1S,4R)-4-(2,6-Diamino-9H-purin-9-yl)cyclopent-2-en-1-yl)methanol; [(1S,4R)-4-(2,6-Diamino-9H-purin-9-yl)cyclopent-2-enyl]methanol; [(1S,4R)-4-(2,6-diaminopurin-9-yl)cyclopent-2-en-1-yl]methanol; (-)-(1S,4R)-4-[2,6-Diamino-9H-purin-9yl]-2- cyclopentene-1-methanol; [4-(6-Amino-2-imino-1,2-dihydro-9H-purin-9-yl)cyclopent-2-en-1-yl]methanolSMILES
OC[C@@H]1C=C[C@H](N2C=NC3=C(N)N=C(N)N=C23)C1InChI
InChI=1S/C11H14N6O/c12-9-8-10(16-11(13)15-9)17(5-14-8)7-2-1-6(3-7)4-18/h1-2,5-7,18H,3-4H2,(H4,12,13,15,16)/t6-,7+/m1/s1설명
Abacavir EP Impurity C also known as Descyclopropyl Abacavir, in various pharmacopoeias, is a highly characterized standard. It meets strict regulatory requirements set by USP, EMA, JP, and BP, making it a crucial component in Abbreviated New Drug Applications (ANDA), New Drug Applications (NDA), and the commercial production of Abacavir. Abacavir EP Impurity C (CAS No: 124752-25-6) or Abacavir USP Related Compound A is a degradation product of Abacavir that is a nucleoside reverse transcriptase inhibitor It acts by chain termination after incorporation into the growing polynucleotide strand and is utilized in the treatment of HIV infection.
References
Kurmi, Moolchand, et al. Stability Behaviour of Antiretroviral Drugs and Their Combinations. 5: Characterization of Novel Degradation Products of Abacavir Sulfate by Mass and Nuclear Magnetic Resonance Spectrometry. Journal of Pharmaceutical and Biomedical Analysis, vol. 134, Feb. 2017, pp. 372 “84, https://doi.org/10.1016/j.jpba.2016.10.019. ?Vukkum, Pallavi. Stress Degradation Behavior of Abacavir Sulfate and Development of a Suitable Stability-Indicating UHPLC Method for the Determination견적 요청
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