Abacavir Related Compound B (CAS No: 141271-12-7) is an impurity of Abacavir that is a carbocyclic 2?-deoxyguanosine nucleoside analog. The mechanism includes its conversion intracellularly to a 2?-deoxyguanosine nucleoside analog that competitively restrains HIV reverse transcriptase and eliminates proviral DNA chain extension.
References
Hervey, Pauline S., and Caroline M. Perry. “Abacavir.†Drugs, vol. 60, no. 2, Aug. 2000, pp. 447–79, https://doi.org/10.2165/00003495-200060020-00015. Jain, Mohit, et al. “A Simple and Sensitive Method for the Ultra Trace Determination of Potential Genotoxic Impurities in Abacavir Sulfate by LC-MS.†Chemical Methodologies, vol. 2, no. 4, Sami Publishing Company, Oct. 2018, pp. 315–23, https://doi.org/10.22034/chemm.2018.66185.
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