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포함 사항: HPLC, MASS/LC-MS, 1H NMR, FT-IR, 함량, 구조 규명 보고서(SER), 그리고 제품에 따라 추가 분석 데이터가 제공됩니다.

118-00-3Adenosine EP Impurity H

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카탈로그 번호:	VE007800
CAS 번호:	118-00-3
분자식:	C10H13N5O5
분자량:	283.2 g/mol

견적 요청

RFQ 목록에 추가

에 대한 추가 정보 CAS 118-00-3

모약물

Adenosine

IUPAC명

2-Amino-9-Beta-D-ribofuranosyl-1,9-dihydro-6H-purin-6-one

Pharmacopeial Synonyms

Guanosine

동의어

guanine riboside; vernine; Guanozin; Guanosin; 2-Amino-1,9-dihydro-9-beta-D-ribofuranosyl-6H-purin-6-one; Guanine-9-beta-D-ribofuranoside; 9-beta-D-Ribofuranosylguanine; Ribofuranoside, guanine-9, beta-D-; 2(3H)-Imino-9-beta-D-ribofuranosyl-9H-purin-6(1H)-one; 2-Amino-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1H-purin-6(9H)-one; 2-Amino-9-beta-D-ribofuranosyl-1,9-dihydro-6H-purin-6-one; 9-.beta.-D-ribofuranosylguanine; [3H]-guanosine; Inosine, 2-amino; Guanine-9-ss–D-ribofuranoside; 9-beta-delta-ribofuranosyl-Guanine

SMILES

O=C1NC(N)=NC2=C1N=CN2[C@H]3[C@@H]([C@@H]([C@@H](CO)O3)O)O

InChI

InChI=1S/C10H13N5O5/c11-10-13-7-4(8(19)14-10)12-2-15(7)9-6(18)5(17)3(1-16)20-9/h2-3,5-6,9,16-18H,1H2,(H3,11,13,14,19)/t3-,5-,6-,9-/m1/s1

Shipping Condition

Ambient Temperature

설명

Adenosine EP Impurity H, identified as guanosine (CAS 118-00-3), is a structurally related nucleoside impurity encountered during adenosine synthesis and stability studies. Molecular formula C10H13N5O5 and exact mass 283.24 Da facilitate mass spectrometric identification with a characteristic [M+H]+ at m/z 284. Reversed-phase HPLC separates guanosine from adenosine with distinct retention behavior and UV absorbance near 254 nm, while 1H and 13C NMR confirm ribofuranosyl and guanine resonances. Water solubility and thermal decomposition profiles support analytical method development. Routine control by validated HPLC and MS methods ensures compliance with pharmacopoeial impurity limits.

References

Lanznaster, Débora, et al. “Guanosine: A Neuromodulator with Therapeutic Potential in Brain Disorders.” Aging and Disease, vol. 7, no. 5, 2016, p. 657, https://doi.org/10.14336/ad.2016.0208. ?