Avatrombopag Nitroso Impurity 2는 avatrombopag의 공정 유래 또는 분해 유래 불순물로 간주되는 구조적으로 정의된 니트로소 관련 화합물이며, 명칭에서 유추되는 N-nitroso 기능기로 인해 니트로사민 위험 범주에 속한다. 분자식 C11H12ClN5OS2, 분자량 329.83 g/mol을 가지며, 염소화 헤테로방향족 골격과 황 헤테로원자는 극성, 이온화 거동, 크로마토그래피 보유 특성에 영향을 준다. 이러한 니트로소 종은 잠재적 유전독성 때문에 ICH M7 관점에서 평가된다. 검출 및 정량에는 일반적으로 LC-MS/MS, 고분해능 LC-MS, 그리고 휘발성이 허용될 경우 GC-MS가 요구된다.
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