Calcitriol EP Impurity B, 즉 1β-Calcitriol 또는 1-epi-Calcitriol은 비타민 D3 유래의 입체이성질체 대사체로서 분자식 C27H44O3, 분자량 416.64 g/mol, CAS 66791-71-7을 가진다. 이 화합물은 C1 위치의 반전으로 calcitriol과 구별되며, 하이드록실기의 β 배향으로 인해 수용체 인식과 대사 거동이 달라진다. 이러한 불순물은 세코스테로이드 물질의 합성 중 또는 저장 중 발생하는 epimerization과 연관되는 경우가 많다. 인접한 epimer의 분리가 필요하므로, 확인과 정량에는 LC-MS/MS, 고해상도 질량분석, 그리고 키랄 또는 역상 HPLC와 NMR 보조 분석이 일반적으로 요구된다.
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