H-Cys-Ser-Asn-Leu-Ser-Thr-Cys-Val-Leu-Gly-Lys-Leu-Ser-Gln-Glu-Leu-His-Lys-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asn-Thr-Gly-Ser-Gly-NH2 (Disulfide bond between Cys1 and Cys7)
Pharmacopeial Synonyms
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동의어
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설명
Des (32,31) Thr is a truncated impurity of procalcitonin characterized by the loss of threonine residues at positions 31 and 32. This variant is readily detected by reversed-phase HPLC and confirmed by LC-MS/MS, exhibiting a mass decrease consistent with the loss of two amino acids and a predictable retention time shift. Its presence can affect assay specificity, quantification accuracy and stability profiles, making targeted monitoring essential during synthesis and purification. Recommended analytical strategies include peptide mapping, high resolution mass spectrometry and peptide specific chromatographic methods to quantify low level occurrence and guide process optimization to minimize formation. Robust characterization supports regulatory compliance and product consistency.
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