에틸 시아노아세테이트, CAS 105-56-6는 시아노아세트산의 에틸 에스터로, 분자식 C5H7NO2 및 분자량 113.11 g/mol을 갖는 반응성 시아노에스터 중간체이다. 불순물 프로파일에서는 에스터화 또는 전이에스터화 반응에서 유래할 수 있으며, 활성 메틸렌 화합물을 사용하는 합성 경로에서 공정 관련 잔류물로 남을 수 있다. 니트릴과 에스터 기능기는 극성 및 분해 패턴을 결정하므로, 미량 동정과 정량에는 LC-MS/MS와 GC-MS가 선호된다. 시아노 기능성 종은 반응성과 독성학적 관련성 때문에 불순물 관리 전략에서 평가가 필요하다.
References
“Solvent-Free Microwave Enhanced Knoevenagel Condensation of Ethyl Cyanoacetate with Aldehydes.†Synthetic Communications, 2021, www.tandfonline.com/doi/abs/10.1080/00397919908086438. “Solvent-Free Synthesis of Ethyl a-Cyanocinnamate in the Presence of CaO.†Synthetic Communications, 2021, www.tandfonline.com/doi/abs/10.1081/SCC-120037918?journalCode=lsyc20. ?
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