에틸렌글리콜, CAS 107-21-1은 분자식 C2H6O2, 분자량 62.07 g/mol의 저분자 지방족 디올이다. 친수성이며 강한 수소결합성을 갖는 용매 및 보습제로서, 다단계 합성 및 정제 공정에서 공정 유래 불순물 또는 잔류 시약으로 관찰될 수 있다. ICH M7 기준의 유전독성 불순물로 분류되지는 않지만, 전신 노출과 용량 의존적 신독성이 독성학적 의미를 갖는다. 정량은 일반적으로 유도체화를 수반하는 헤드스페이스 또는 직접 GC-MS, 또는 휘발성 기반 측정이 제한되는 복잡한 매트릭스에서는 LC-MS/MS를 통해 수행된다.
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