O-Desethyl Dapagliflozin은 Dapagliflozin FP-Impurity A로도 지칭되며, SGLT2 억제제 다파글리플로진의 염소화 데에틸 유사체로서 CAS 864070-37-1에 해당한다. 분자식은 C19H21ClO6, 분자량은 380.82 g/mol이며, 모체 화합물의 페녹시 산소에 결합한 에틸기가 제거된 구조로서 합성 중간체, 공정 유래 부산물 또는 가수분해·탈알킬화에 따른 분해산과 일치한다. 검출과 정량에는 일반적으로 LC-MS/MS, 고분해능 LC-MS, 보완적 LC-UV가 요구되며, 구조 확증에는 NMR이 활용된다. 관련 불순물로서 통상 불순물 관리 체계 내에서 평가된다.
References
Haider, Kashif, et al. “Synthetic Strategy and SAR Studies of C-Glucoside Heteroaryls as SGLT2 Inhibitor: A Review.†European Journal of Medicinal Chemistry, vol. 184, Dec. 2019, p. 111773, https://doi.org/10.1016/j.ejmech.2019.111773.?Docherty, Kieran F., et al. “Effects of Dapagliflozin in DAPA-HF according to Background Heart Failure Therapy.†European Heart Journal, vol. 41, no. 25, Mar. 2020, pp. 2379–92, https://doi.org/10.1093/eurheartj/ehaa183.
To provide the best experiences, we use technologies like cookies to store and/or access device information. Consenting to these technologies will allow us to process data such as browsing behavior or unique IDs on this site. Not consenting or withdrawing consent, may adversely affect certain features and functions.
Functional
Always active
The technical storage or access is strictly necessary for the legitimate purpose of enabling the use of a specific service explicitly requested by the subscriber or user, or for the sole purpose of carrying out the transmission of a communication over an electronic communications network.
Preferences
The technical storage or access is necessary for the legitimate purpose of storing preferences that are not requested by the subscriber or user.
Statistics
The technical storage or access that is used exclusively for statistical purposes.The technical storage or access that is used exclusively for anonymous statistical purposes. Without a subpoena, voluntary compliance on the part of your Internet Service Provider, or additional records from a third party, information stored or retrieved for this purpose alone cannot usually be used to identify you.
Marketing
The technical storage or access is required to create user profiles to send advertising, or to track the user on a website or across several websites for similar marketing purposes.
To provide the best experiences, we use technologies like cookies to store and/or access device information. Consenting to these technologies will allow us to process data such as browsing behavior or unique IDs on this site. Not consenting or withdrawing consent, may adversely affect certain features and functions.
Functional
Always active
The technical storage or access is strictly necessary for the legitimate purpose of enabling the use of a specific service explicitly requested by the subscriber or user, or for the sole purpose of carrying out the transmission of a communication over an electronic communications network.
Preferences
The technical storage or access is necessary for the legitimate purpose of storing preferences that are not requested by the subscriber or user.
Statistics
The technical storage or access that is used exclusively for statistical purposes.The technical storage or access that is used exclusively for anonymous statistical purposes. Without a subpoena, voluntary compliance on the part of your Internet Service Provider, or additional records from a third party, information stored or retrieved for this purpose alone cannot usually be used to identify you.
Marketing
The technical storage or access is required to create user profiles to send advertising, or to track the user on a website or across several websites for similar marketing purposes.
