Acetovanillone Impurities

Acetovanillone has been used for the treatment of Bronchial Asthma and Chronic Obstructive Pulmonary Disease.

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Impurity structure Parent Drug Name Name of Impurity Catalogue No. CAS No.
p-O-Methyl-isoproterenol Acetovanillone

p-O-Methyl-isoproterenol

VE007786 3413-49-8
1-(4-Benzyloxy-3-methoxyphenyl)ethanone Acetovanillone

1-(4-Benzyloxy-3-methoxyphenyl)ethanone

VE007785 1835-11-6
1-Isopropyl-6-methoxyindoline-3,5-diol Acetovanillone

1-Isopropyl-6-methoxyindoline-3,5-diol

VE007784 N/A

Acetovanillone Related Compound

By regulating PI3K/Akt/mTOR and Nrf2 signaling, it protects against cyclophosphamide-induced acute lung damage.

References

  • PubChem. “Acetovanillone.” @Pubchem, PubChem, 2023, pubchem.ncbi.nlm.nih.gov/compound/2214. Accessed 10 June 2023.
  • Stefanska, Joanna, and Rafał Pawliczak. Apocynin: Molecular Aptitudes. Jan. 2008, pp. 1–10, https://doi.org/10.1155/2008/106507. Accessed 10 June 2023. ‌

FAQ

What is the use of acetovanillone?

It is a non-steroidal anti-inflammatory,non-narcotic analgesic medicine,   peripheral nervous system drug, antirheumatic drug,  [NAD(P)H oxidase (H2O2-forming)] inhibitor, and plant metabolite.

What is the mechanism of action of acetovanillone in asthma?

In various research scenarios including phagocytic and nonphagocytic cells, Acetovanillone has been utilized as an effective inhibitor of the complex NADPH-oxidase. , although it includes preventing the cytosolic component p47phox of the NADPH-oxidase complex from translocating to the membrane.

Is acetovanillone used in anti-inflammatory?

It reduced adhesion of the monocytic cell line U937 to TNF-treated human umbilical vein endothelial cells, reduction of neutrophil oxidative burst, neutrophil-mediated oxidative damage, inhibition of inflammation-mediated cartilage destruction, reduction of polymorphonuclear granulocyte chemotaxis, inhibition of peroxynitrite.