Acetyltributyl Citrate Impurities

Acitretin is a medication employed for treating severe skin conditions such as psoriasis.

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Impurity structure Parent Drug Name Name of Impurity Catalogue No. CAS No.
Acetyltributyl Citrate Impurity A Acetyltributyl Citrate

Acetyltributyl Citrate Impurity A

VE007788 77-94-1
Acetyltributyl Citrate Impurity B Acetyltributyl Citrate

Acetyltributyl Citrate Impurity B

VE007791 7568-58-3
Acetyltributyl Citrate Impurity C Acetyltributyl Citrate

Acetyltributyl Citrate Impurity C

VE007792 N/A

Acetyltributyl Citrate Related Compound

It operates by permitting regular skin development as well as growth. Adults with severe psoriasis are treated with acitretin. it possesses anti-inflammatory as well as anti-proliferative properties. via restoring epithelial keratinocyte differentiation.

References

  • “Acitretin: MedlinePlus Drug Information.” Medlineplus.gov, 2015, medlineplus.gov/druginfo/meds/a601010.html#:~:text=Acitretin%20is%20in%20a%20class%20of%20medications%20called%20retinoids. Accessed 12 June 2023. ‌
  • “Acitretin: Uses, Interactions, Mechanism of Action | DrugBank Online.” Drugbank.com, DrugBank, 2023, go.drugbank.com/drugs/DB00459. Accessed 12 June 2023. ‌
  • Zito, Patrick M., and Thomas Mazzoni. “Acitretin.” Nih.gov, StatPearls Publishing, 25 Sept. 2022, www.ncbi.nlm.nih.gov/books/NBK519571/#:~:text=Acitretin%20is%20FDA%2Dapproved%20for,combination%20therapy%20with%20biologic%20therapies. Accessed 12 June 2023. ‌

FAQ

Acitretin is belong to what drug class?

Acitretin belongs to the retinoids class of medicines.it is used to treat severe psoriasis (abnormal skin cell development that results in red, thickened, or scaly skin).

What is the mechanism of action of Acitretin?

Acitretin acts by decreasing the excessive cell proliferation and keratinization found in psoriasis (the process by which skin cells thicken because of the deposition of a protein within them). As a result, it lowers skin thickness, plaque development, and scaling. The mechanism of action of acitretin is uncertain, however, it is thought to function by targeting particular receptors in the skin (retinoid receptors such as RXR and RAR) that assist normalize the development cycle of skin cells.

Is acitretin effective in treating psoriasis?

Acitretin is authorized by the FDA for the treatment of psoriasis (severe plaque-type psoriasis, pustular psoriasis generalized pustular psoriasis localized), in combination with ultraviolet B (UVB) or psoralen ultraviolet A (PUVA), in combination with cyclosporine, and in combination with biologic treatments.