Acriflavine Impurities

It is effective against a wide range of malignancies, including osteosarcoma, breast, brain, lung, liver, colon, ovarian, and pancreatic cancers, as well as leukemia.

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Impurity structure Parent Drug Name Name of Impurity Catalogue No. CAS No.
Acriflavine HCl (Mixture of Acriflavinium Chloride and Proflavine HCl) Aciflavine

Acriflavine HCl (Mixture of Acriflavinium Chloride and Proflavine HCl)

VE0012019 65589-70-0
Proflavine Hemisulfate Acriflavine

Proflavine Hemisulfate

VL5360002 3237-53-4

Acriflavine Related Compound

It is currently mostly used to treat parasitic infections as a topical antiseptic. also used to cure wounds with infections and clean the skin. It has the potential to be utilized as a fungicide.

References

  • Kawai, Mako, and Junichi Yamagishi. Mechanisms of Action of Acriflavine: Electron Microscopic Study of Cell Wall Changes Induced inStaphylococcus Aureusby Acriflavine. no. 9, Sept. 2009, pp. 481–86, https://doi.org/10.1111/j.1348-0421.2009.00151.x. Accessed 13 June 2023.
  • ‌Gabriel, Iwona. “Acridines” as New Horizons in Antifungal Treatment. no. 7, Mar. 2020, pp. 1480–80, https://doi.org/10.3390/molecules25071480. Accessed 13 June 2023.
  • ‌“Acriflavine: Uses, Interactions, Mechanism of Action | DrugBank Online.” Drugbank.com, DrugBank, 2023, go.drugbank.com/drugs/DB13373. Accessed 13 June 2023.

FAQ

What is the mechanism of action of acriflavine in Staphylococcus aureus cell wall modifications?

In S. aureus, acriflavine treatment increases cell wall thickness in both cross and peripheral walls. These findings imply that the synthesis of the cross and peripheral walls is governed by two distinct mechanisms. It is possible that acriflavine works on two distinct targets that govern these processes. Acriflavine’s method of action may include targeting proteins involved in cell wall production.

Is Acriflavine an antifungal?

Acriflavine is an antiseptic and efficient parasitic infection treatment. It can be used as a fungicide. had been previously established that the drug was capable of inducing mutations in yeast. Saccharomyces cerevisiae and Trypanosomatidae kinetoplast loss.

What is acriflavine used for?

Acriflavine is a topical antiseptic used to heal wounds with infections and clean the skin. It is an effective antibacterial medicine. It is effective in treating, mouth, as well as oral fungus, ulcers, and germs.